中華民國血液病學會

1. Which statement is false in BNS?

A. A histological biopsy of the cerebrum or meninges demonstrating a LPL is the golden standard for the diagnosis of BNS, and Biopsy should be attempted prior to steroid administration.

B. Patients had very low (less than 5 cells/mm3) counts of LPC in the CSF, and it was suggested that symptoms were caused by IgM deposits rather than by cellular infiltration of the CNS.

C. Image finding (PET/CT or MRI) of the brain and spinal cord is essential for the diagnosis of CNS lymphomas.

D. MRI is a very sensitive technique for the detection of malignant infiltration of the CNS, it can differentiate between the different histological entities of CNS lymphoma and it can obviate the need for CSF or tissue sampling.

2. Which statement is true in BNS?

A. Sensory symptoms including paresthesias, pins and needles sensations, and pain may represent in BNS.

B. Seizures, cognitive decline, aphasia, psychiatric symptoms, cerebellar dysfunction, impairment of consciousness including coma, and paresis may represent in BNS.

C. There is no clinical picture or specific symptom(s) that can prove or exclude BNS.

D. All above.

3. Which statement is false in BNS?

A. According to NCCN guidelines zanubrutinib and ibrutinib are preferred regimens for symptomatic BN.

B. Treatment should be offered to symptomatic patients in whom a definitive diagnosis of BNS has been established.

C. The role of autologous stem cell transplantation (ASCT) is clear and can be considered in young patients with aggressive disease behavior.

D. RT may be considered in BNS patients with localized spinal involvement in whom toxicity can be limited.

The correct answer is as follows

1.Which statement of is false?

A: (D) MRI is a very sensitive technique for the detection of malignant infiltration of the CNS,it can differentiate between the different histological entities of CNS lymphoma and it can obviate the need for CSF or tissue sampling.

2.Which statement of is false?

A: (D) All above.

3.Which statement is false about treatment response criteria in NCCN?

A: (C) The role of autologous stem cell transplantation (ASCT) is clear and can be considered in young patients with aggressive disease behavior.